Bacopa monnieri extract

Bacopa monnieri extract
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Bacopa monnieri extract

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Technical Data Sheet

 

Product code

030123

Product

Bacopa Monnieri Extract

Specification

Bacosides 50% UV

Part used

Stem Leaf

Botanical source

Bacopa monnieri (L.) wettst.

 

Items

Specification

Methods

Physical & chemical

Color

 

Brown yellow

 

Organoleptic

Odor

Characteristic

Organoleptic

Appearance

Fine powder

Organoleptic

Analytical quality

Identification

 

Identical to R.S. sample

 

HPTLC

Sieve analysis

100% through 80 mesh

Eur.Ph.<2.9.12>

Loss on drying

≤5.0%

Eur.Ph.7.0 [2.8.17]

Total ash

≤10.0%

Eur.Ph.<2.4.16>

Bulk density

40~60g/100mL

Eur.Ph.<2.9.34>

Tap density

60~90g/100mL

Eur.Ph.<2.9.34>

Bacosides

≥50.0%

UV

Contaminants

Lead (Pb)

 

≤3.0mg/kg

 

Eur.Ph.<2.2.58>ICP-MS

Arsenic (As)

≤2.0mg/kg

Eur.Ph.<2.2.58>ICP-MS

Cadmium (Cd)

≤1.0mg/kg

Eur.Ph.<2.2.58>ICP-MS

Mercury (Hg)

≤0.1mg/kg

Eur.Ph.<2.2.58>ICP-MS

Solvents residue

Meet Eur.Ph. requirements

Eur.Ph.<2.4.24>

Pesticides residue

Meet Eur.Ph. requirements

Eur.Ph.<2.4.13>

Microbiological

Total plate count

 

≤10000cfu/g

 

Eur.Ph.<2.6.12>

Yeast & mold

≤1000cfu/g

Eur.Ph.<2.6.12>

E. Coli.

Negative

Eur.Ph.<2.6.13>

Salmonella

Negative

Eur.Ph.<2.6.13>

General Status

Non-Irradiation

 

≤700

 

EN13751:2002<PSL>

Net weight: 25kgs/Drum or Carton;

Gross weight: 27.5Kgs±0.5kg/Drum.

Packing size: Drum.I.D.35×H51cm; Carton 36cm×36cm×45cm

24 months under in a well-closed container and away from moisture, light, oxygen.

Packed in paper-drums or carton with two plastic-bags inside.

 

FLOW CHART OF Bacopa monnieri extract 50%

 

Bacopa monnieri extract

 

Bacopa is a plant that has been used in traditional Indian Ayurvedic medicine. Do not confuse bacopa with gotu kola - both plants are sometimes called Brahmi.

 

Bacopa is commonly used for Alzheimer disease, memory and thinking skills (cognitive function), anxiety, and attention deficit-hyperactivity disorder (ADHD), but there is limited scientific research to support these uses.

 

How does it work 

Bacopa might increase certain brain chemicals that are involved in thinking, learning, and memory. Some research suggests that it might also protect brain cells from chemicals involved in Alzheimer disease.

 

Uses & Effectiveness

Possibly Ineffective for

A long-term disorder of the large intestines that causes stomach pain (irritable bowel syndrome or IBS). Bacopa does not seem to help keep IBS symptoms from returning after they have gone away for a while.

 

Insufficient Evidence for

Attention deficit-hyperactivity disorder (ADHD). It is unclear if bacopa is beneficial for reducing symptoms of ADHD.

 

Memory and thinking skills (cognitive function). Some research shows that bacopa improves some memory and thinking skills, but not all research agrees.

 

Depression. Early research shows that taking bacopa along with citalopram, an antidepressant, helps to reduce symptoms in people who have depression and don't get full relief from citalopram.

Alzheimer disease.

Back pain.

Heart failure and fluid build up in the body (congestive heart failure or CHF).

High blood pressure.

Insomnia.

Rheumatoid arthritis (RA).

Sexual problems that prevent satisfaction during sexual activity.

Other conditions.

 

More evidence is needed to rate bacopa for these uses.

 

Side Effects

When taken by mouth: Bacopa extract is POSSIBLY SAFE for adults when used for up to 12 weeks. Common side effects include increased bowel movements, stomach cramps, nausea, dry mouth, and fatigue.

 

Special Precautions and Warnings

Pregnancy and breast-feeding: There isn't enough reliable information to know if bacopa is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

 

Children: Bacopa is POSSIBLY SAFE when taken by mouth by children 6-12 years old for up to 6 months.

 

Slow heart rate (bradycardia): Bacopa might slow down the heart rate. This could be a problem in people who already have a slow heart rate.

 

Gastrointestinal tract blockage: Bacopa might cause "congestion" in the intestines. This might cause problems in people who have a blockage in their intestines.

 

Ulcers: Bacopa might increase secretions in the stomach and intestines. There is concern that this could worsen ulcers.

 

Lung conditions: Bacopa might increase fluid secretions in the lung. There is concern that this could worsen lung conditions such as asthma or a lung disease that makes it harder to breathe (chronic obstructive pulmonary disease or COPD).

 

Thyroid disorders: Bacopa might increase levels of thyroid hormone. Bacopa should be used cautiously or avoided if you have a thyroid condition or take thyroid hormone medications.

 

Urinary tract obstruction: Bacopa might increase secretions in the urinary tract. There is concern that this could worsen urinary obstruction.
 

Interactions

Moderate Interaction

Be cautious with this combination

 

Drying medications (Anticholinergic drugs) interacts with BACOPA

Bacopa might increase levels of certain chemicals in the body that work in the brain, heart, and elsewhere. Some drying medications called "anticholinergic drugs" can also affect these same chemicals, but in a different way. These drying medications might decrease the effects of bacopa, and bacopa might decrease the effects of drying medications.

Some of these drying medications include atropine, scopolamine, some medications used for allergies (antihistamines), and some medications used for depression (antidepressants).

 

Various medications used for glaucoma, Alzheimer disease, and other conditions (Cholinergic drugs) interacts with BACOPA

Bacopa might increase certain chemicals in the brain, heart, and elsewhere in the body. Some medications used for glaucoma, Alzheimer disease, and other conditions also affect these chemicals. Taking bacopa with these medications might increase the chance of side effects.

Some of the medications used for glaucoma, Alzheimer disease, and other conditions include pilocarpine (Pilocar and others), donepezil (Aricept), tacrine (Cognex), and others.

 

Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with BACOPA

Some medications are changed and broken down by the liver. Bacopa might decrease how quickly the liver breaks down these medications. Taking bacopa along with these medications can increase their effects and side effects. Before taking bacopa, talk to your healthcare provider if you take any medications that are changed by the liver.

Some of these medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), zileuton (Zyflo), zolmitriptan (Zomig), and others.

 

Medications changed by the liver (Cytochrome P450 2C19 (CYP2C19) substrates) interacts with BACOPA

Some medications are changed and broken down by the liver. Bacopa might decrease how quickly the liver breaks down these medications. Taking bacopa along with these medications can increase their effects and side effects. Before taking bacopa, talk to your healthcare provider if you take any medications that are changed by the liver.

Some medications that are changed by the liver include amitriptyline (Elavil), carisoprodol (Soma), citalopram (Celexa), diazepam (Valium), lansoprazole (Prevacid), omeprazole (Prilosec), phenytoin (Dilantin), warfarin, and many others.

 

Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates) interacts with BACOPA

Some medications are changed and broken down by the liver. Bacopa might decrease how quickly the liver breaks down these medications. Taking bacopa along with these medications can increase their effects and side effects. Before taking bacopa, talk to your healthcare provider if you take any medications that are changed by the liver.

Some medications that are changed by the liver include celecoxib (Celebrex), diclofenac (Voltaren), fluvastatin (Lescol), glipizide (Glucotrol), ibuprofen (Advil, Motrin), irbesartan (Avapro), losartan (Cozaar), phenytoin (Dilantin), piroxicam (Feldene), tamoxifen (Nolvadex), tolbutamide (Tolinase), torsemide (Demadex), warfarin (Coumadin), and others.

 

Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with BACOPA

Some medications are changed and broken down by the liver. Bacopa might decrease how quickly the liver breaks down these medications. Taking bacopa along with these medications can increase their effects and side effects. Before taking bacopa, talk to your healthcare provider if you take any medications that are changed by the liver.

Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others.

 

Minor Interaction

Be watchful with this combination

 

Thyroid hormone interacts with BACOPA

The body naturally produces thyroid hormones. Bacopa might increase how much thyroid hormone is produced. Taking bacopa with thyroid hormone might cause too much thyroid hormone in the body, and increase its effects and side effects.

 

Dosing

The appropriate dose of bacopa depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for bacopa. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

 

 

From https://www.webmd.com/vitamins/ai/ingredientmono-761/bacopa

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