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Cissus quadrangularis extract
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Cissus quadrangularis extract

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Cissus quadrangularis is a plant that’s rich in vitamin C and antioxidants. It has been used to treat an array of health conditions for centuries, and, today, its extracts are widely available as herbal supplements.
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Cissus quadrangularis is a plant that’s rich in vitamin C and antioxidants. It has been used to treat an array of health conditions for centuries, and, today, its extracts are widely available as herbal supplements.

It’s used as an herbal supplement to treat conditions such as hemorrhoids, bone loss, allergies, asthma, and diabetes. Research backing many of these uses is weak or has failed to show any benefits.

Studies show that Cissus quadrangularis may improve bone health and reduce joint pain. A small body of evidence suggests it might also help prevent metabolic syndrome, but more research is needed.

Most Cissus quadrangularis supplements are available in doses of 500 or 1,000 mg per day. However, studies show that doses of 300–3,200 mg are safe for most people.

 

 

Technical Data Sheet

 

Product code

030557

Product

Cissus Quadrangularis Extract 

Specification

Ketosterones 40%,W/W

Part used

Herb

Botanical source

Cissus Quadrangularis L

 

Items

Specification

Methods

Physical & chemical

Color

 

Brown

 

Organoleptic

Odor

Characteristic

Organoleptic

Appearance

Fine powder

Organoleptic

Analytical quality

Identification

 

Identical to R.S. sample

 

HPTLC

Sieve analysis

100% through 80 mesh

Eur.Ph.<2.9.12>

Loss on drying

≤5.0%

Eur.Ph.7.0 [2.8.17]

Total ash

≤10.0%

Eur.Ph.<2.4.16>

Bulk density

40~60g/100mL

Eur.Ph.<2.9.34>

Tap density

60~90g/100mL

Eur.Ph.<2.9.34>

Active ingredient

ketosterones 40%

W/W

Contaminants

Lead (Pb)

 

≤3.0mg/kg

 

Eur.Ph.<2.2.58>ICP-MS

Arsenic (As)

≤2.0mg/kg

Eur.Ph.<2.2.58>ICP-MS

Cadmium (Cd)

≤1.0mg/kg

Eur.Ph.<2.2.58>ICP-MS

Mercury (Hg)

≤0.1mg/kg

Eur.Ph.<2.2.58>ICP-MS

Solvents residue

Meet Eur.Ph. Requirements

Eur.Ph.<2.4.24>

Pesticides residue

Meet Eur.Ph. Requirements

Eur.Ph.<2.4.13>

Microbiological

Total plate count

 

≤10000cfu/g

 

Eur.Ph.<2.6.12>

Yeast & mold

≤1000cfu/g

Eur.Ph.<2.6.12>

E. Coli.

Negative

Eur.Ph.<2.6.13>

Salmonella

Negative

Eur.Ph.<2.6.13>

General Status

Non-Irradiation

 

≤700

 

EN13751:2002<PSL>

Net weight: 25kgs/Drum

Gross weight: 27.5Kgs±0.5kg/Drum.

Packing size: Drum.I.D.35×H45cm

24 months under in a well-closed container and away from moisture, light, oxygen.

Packed in paper-drums or carton with two plastic-bags inside.

 

FLOW CHART OF Cissus quadrangularis extract

 

Cissus quadrangularis extract

 

Cissus quadrangularis is a vine that grows in Africa and parts of Asia. It is one of the most commonly used medicinal plants in Thailand, and is also used in traditional African and Ayurvedic medicine. All parts of the plant are used for medicine.

 

Cissus quadrangularis is commonly used for bone health and weight loss. It is also used for conditions such as diabetes,high cholesterol, hemorrhoids, and many others, but there is no good scientific evidence to support these uses.

 

How does it work 

There is not enough information to know how Cissus quadrangularis might work for medicinal purposes in people. Test tube studies and research in animals show that it has antioxidant, analgesic, and anti-inflammatory properties. It might have activity against the organism that causes malaria.

 

Uses & Effectiveness

Possibly Effective for

Obesity. Most research shows that taking Cissus quadrangularis extract, alone or with other ingredients, reduces weight by a small amount in people who are overweight or obese. But many of these studies are low to moderate quality and lasted for only 6-10 weeks. Longer-term, larger studies are need to confirm these results.

 

Insufficient Evidence for

Fractures. Early research shows that taking Cissus quadrangularis dried herb preparations or extracts can decrease pain and swelling and improve the rate of healing in people with various types of bone fractures. However, this research is generally low quality.

Hemorrhoids. Early research shows that taking Cissus quadrangularis by mouth for 1-2 weeks, or applying a cream containing Cissus quadrangularis to hemorrhoids for 1 week, does not improve hemorrhoid symptoms.

Joint pain. Early research shows that taking a Cissus quadrangularis product for 8 weeks decreases pain and stiffness in men with joint pain caused by exercise.

Low bone mass (osteopenia). Early research shows that taking Cissus quadrangularis with other ingredients might help to increase bone mass in people with low bone mass.

Allergies.

Asthma.

Bodybuilding.

Cancer.

Diabetes.

Gout.

Heart disease risk factors that occur together (metabolic syndrome).

High cholesterol.

Loss of appetite (anorexia).

Malaria.

Osteoporosis.

Pain.

Painful menstrual periods.

Peptic ulcer disease (PUD).

Rheumatoid arthritis.

Scurvy.

Seizures.

Upset stomach.

Wound healing.

Other conditions.

 

More evidence is needed to rate the effectiveness of Cissus quadrangularis for these uses.

 

Side Effects

When taken by mouth: Cissus quadrangularis is POSSIBLY SAFE when taken by mouth for up to 10 weeks. Cissus quadrangularis can cause side effects such as headache, intestinal gas, dry mouth, diarrhea, and insomnia. There is not enough information to know how often these side effects might occur.

 

The long-term safety of Cissus quadrangularis is not known.

 

Special Precautions and Warnings

Pregnancy and breast-feeding: There isn't enough reliable information to know if Cissus quadrangularis is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

 

Diabetes: Cissus quadrangularis might lower blood sugar. Taking Cissus quadrangularis along with medications for diabetes might lower blood sugar too much. Watch for signs of low blood sugar (hypoglycemia) and monitor your blood sugar levels closely if you have diabetes and use Cissus quadrangularis.

 

Surgery: Cissus quadrangularis might lower blood sugar and could interfere with blood sugar control during and after surgical procedures. Stop using Cissus quadrangularis at least 2 weeks before a scheduled surgery.

 

Interactions

Moderate Interaction

Be cautious with this combination

Medications for diabetes (Antidiabetes drugs) interacts with CISSUS QUADRANGULARIS

Cissus quadrangularis might lower blood sugar. Diabetes medications are also used to lower blood sugar. Taking Cissus quadrangularis along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.

Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.

 

Dosing

The following doses have been studied in scientific research:

 

ADULTS

BY MOUTH:

For obesity: 300 mg of Cissuc quadrangularis extract has been taken once daily or in two divided doses daily for 6-10 weeks.

 

From https://www.webmd.com/vitamins/ai/ingredientmono-1166/cissus-quadrangularis

 

 

Keyword:
Cissus quadrangularis
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