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Resveratrol
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Resveratrol

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Resveratrol is a chemical mostly found in red grapes and products made from these grapes (wine, juice). It may be helpful for hay fever and weight loss. Resveratrol might have many effects in the body, including expanding blood vessels and reducing blood clotting. It may also decrease pain and swelling, reduce levels of sugar in the blood, and help the body fight against disease. Resveratrol is most commonly used for high cholesterol, cancer, heart disease, and many other conditions. But there is no strong evidence to support resveratrol for any use.
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Product description
Parameters

 

Technical Data Sheet

 

Product code

030065

Product

Giant knotweed extract

Specification

Trans-Resveratrol≥98.0%, HPLC

Part used

Root

Botanical source

Polygonum cuspidatum L.

Solvents used

Water & Ethanol

Carrier

None

 

Items

Specification

Methods

Physical & chemical

Color

 

White to off-white

 

 

Organoleptic

Odor

Characteristic

Organoleptic

Appearance

Fine powder

Organoleptic

Analytical quality

Identification

 

Identical to R.S. sample

 

HPTLC

Sieve analysis

90% through 80 mesh

Eur.Ph.<2.9.12>

Loss on drying

5.0%

Eur.Ph.7.0 [2.8.17]

Total ash

≤10.0%

Eur.Ph.<2.4.16>

Bulk density

40~60g/100mL

Eur.Ph.<2.9.34>

Tap density

60~90g/100mL

Eur.Ph.<2.9.34>

Trans-Resveratrol

98.0%

HPLC

Contaminants

Lead (Pb)

 

≤3.0mg/kg

 

Eur.Ph.<2.2.58>ICP-MS

Arsenic (As)

≤2.0mg/kg

Eur.Ph.<2.2.58>ICP-MS

Cadmium (Cd)

≤1.0mg/kg

Eur.Ph.<2.2.58>ICP-MS

Mercury (Hg)

≤0.1mg/kg

Eur.Ph.<2.2.58>ICP-MS

Solvents residue

Meet Eur.Ph. Requirements

Eur.Ph.<2.4.24>

Pesticides residue

Meet Eur.Ph. Requirements

Eur.Ph.<2.4.13>

Microbiological

Total plate count

 

≤10000cfu/g

 

Eur.Ph.<2.6.12>

Yeast & mold

≤1000cfu/g

Eur.Ph.<2.6.12>

E. Coli.

Negative

Eur.Ph.<2.6.13>

Salmonella

Negative

Eur.Ph.<2.6.13>

General Status

Non-Irradiation

 

≤700

 

EN13751:2002<PSL>

Net weight: 25kgs/Drum

Gross weight: 27.5Kgs±0.5kg/Drum.

Packing size: Drum.I.D.35×H45cm

24 months under in a well-closed container and away from moisture, light, oxygen.

Packed in paper-drums or carton with two plastic-bags inside.

 

FLOW CHART of Giant knotweed extract 98% resveratrol

 

Resveratrol   

 

Resveratrol is a chemical mostly found in red grapes and products made from these grapes (wine, juice). It may be helpful for hay fever and weight loss.

 

Resveratrol might have many effects in the body, including expanding blood vessels and reducing blood clotting. It may also decrease pain and swelling, reduce levels of sugar in the blood, and help the body fight against disease.

 

Resveratrol is most commonly used for high cholesterol, cancer, heart disease, and many other conditions. But there is no strong evidence to support resveratrol for any use.

 

How does it work

 

Uses & Effectiveness

Possibly Effective for

Hay fever. Using a nasal spray containing resveratrol three times daily for 4 weeks seems to reduce allergy symptoms in adults with seasonal allergies. Using a nasal spray containing resveratrol and beta-glucans three times daily for 2 months also seems to reduce allergy symptoms in children with seasonal allergies.

Obesity. Taking resveratrol by mouth seems to increase weight loss in overweight and obese adults. But it doesn't seem to improve blood pressure, glucose control, or levels of cholesterol and other fats.

 

Possibly Ineffective for

Heart disease. People who consume higher amounts of dietary resveratrol do not seem to have a lower risk of heart disease compared to people who consume lower amounts. Also, taking resveratrol by mouth does not seem to improve levels of cholesterol or blood fats called triglycerides in people at risk for heart disease.

 

High cholesterol. Taking resveratrol by mouth does not improve levels of cholesterol or blood fats called triglycerides.

 

A grouping of symptoms that increase the risk of diabetes, heart disease, and stroke (metabolic syndrome). Taking resveratrol by mouth doesn't seem to lower blood pressure, blood sugar, or cholesterol in people with metabolic syndrome.

 

Build up of fat in the liver in people who drink little or no alcohol (nonalcoholic fatty liver disease or NAFLD). Taking resveratrol by mouth doesn't improve liver function, liver scarring, or cholesterol levels in people with NAFLD.

 

There is interest in using resveratrol for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.

 

Side Effects

 

When taken by mouth: People often consume resveratrol in small amounts in foods. Resveratrol supplements are possibly safe when taken by mouth in doses up to 1500 mg daily for up to 3 months. Higher doses of up to 2000-3000 mg daily have been used safely for 2-6 months. But these higher doses are more likely to cause stomach upset.

 

When applied to the skin: Resveratrol is possibly safe when used for up to 30 days.

 

When sprayed into the nose: Resveratrol is possibly safe when used for up to 4 weeks.

 

Special Precautions and Warnings

Pregnancy and breast-feeding: Resveratrol is likely safe when used in amounts found in some foods. However, during pregnancy and breast-feeding, the source of resveratrol is important. Resveratrol is found in grape skins, grape juice, wine, and other food sources. Wine should not be used as a source of resveratrol when pregnant or breast-feeding.

 

Children: People often consume resveratrol in small amounts in foods. But there isn't enough reliable information to know if it safe to take by mouth in larger amounts. Resveratrol is possibly safe in children when sprayed in the nose for up to 2 months.

 

Bleeding disorders: Resveratrol might slow blood clotting and increase the risk of bleeding in people with bleeding disorders.

 

Hormone-sensitive condition such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Resveratrol might act like estrogen. If you have any condition that might be made worse by exposure to estrogen, don't use resveratrol.

 

Surgery: Resveratrol might increase the risk of bleeding during and after surgery. Stop using resveratrol at least 2 weeks before a scheduled surgery.

 

Interactions

Moderate Interaction

Be cautious with this combination

 

Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with RESVERATROL

Some medications are changed and broken down by the liver. Resveratrol might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

 

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with RESVERATROL

Resveratrol might slow blood clotting. Taking resveratrol along with medications that also slow blood clotting might increase the risk of bruising and bleeding.

 

Medications changed by the liver (Cytochrome P450 1A1 (CYP1A1) substrates) interacts with RESVERATROL

Some medications are changed and broken down by the liver. Resveratrol might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

 

Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with RESVERATROL

Some medications are changed and broken down by the liver. Resveratrol might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

 

Medications changed by the liver (Cytochrome P450 1B1 (CYP1B1) substrates) interacts with RESVERATROL

Some medications are changed and broken down by the liver. Resveratrol might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

 

Medications changed by the liver (Cytochrome P450 2C19 (CYP2C19) substrates) interacts with RESVERATROL

Some medications are changed and broken down by the liver. Resveratrol might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

 

Medications changed by the liver (Cytochrome P450 2E1 (CYP2E1) substrates) interacts with RESVERATROL

Some medications are changed and broken down by the liver. Resveratrol might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

 

Dosing

Resveratrol has most often been used by adults in doses of 250-1000 mg by mouth daily for up to 3 months. It is also sometimes used in nasal sprays. Speak with a healthcare provider to find out what dose might be best for a specific condition.

 

from:https://www.webmd.com/vitamins/ai/ingredientmono-307/resveratrol

 

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