Spermidine

Spermidine
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Spermidine

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Spermidine is a polyamine compound (C7H19N3) found in ribosomes and living tissues, and having various metabolic functions within organisms. It was originally isolated from semen.

Function

Spermidine is an aliphatic polyamine. Spermidine synthase (SPDS) catalyzes its formation from putrescine. It is a precursor to other polyamines, such as spermine and its structural isomer thermospermine.

Spermidine synchronizes an array of biological processes (such as Ca2+, Na+, K+ -ATPase) thus maintaining membrane potential and controlling intracellular pH and volume. Spermidine regulates biological processes, such as Ca2+ influx by glutamatergic N-methyl-d-aspartate receptor (NMDA receptor), which has been associated with nitric oxide synthase (NOS) and cGMP/PKG pathway activation and a decrease of Na+,K+-ATPase activity in cerebral cortex synaptosomes.

Spermidine is a longevity agent in mammals due to various mechanisms of action, which are just beginning to be understood. Autophagy is the main mechanism at the molecular level, but evidence has been found for other mechanisms, including inflammation reduction, lipid metabolism, and regulation of cell growth, proliferation and death.

Spermidine is known to regulate plant growth, assisting the in vitro process of transcribing RNA, and inhibition of NOS. Also, spermidine is a precursor to other polyamines, such as spermine and thermospermine, some of which contribute to tolerance against drought and salinity in plants.

Spermidine has been tested and discovered to encourage hair shaft elongation and lengthen hair growth. Spermidine has also been found to “upregulate expression of the epithelial stem cell-associated keratins K15 and K19, and dose-dependently modulated K15 promoter activity in situ and the colony forming efficiency, proliferation and K15 expression of isolated human K15-GFP+ cells in vitro.”

Biochemical actions

Spermidine's known actions include: Inhibits neuronal nitric oxide synthase (nNOS); Binds and precipitates DNA; Polyamine plant growth regulator

Sources

Good dietary sources of spermidine are aged cheese, mushrooms, soy products, legumes, corn, and whole grains. Spermidine is plentiful in a Mediterranean diet. For comparison: The spermidine content in human seminal plasma varies between approx. 15 and 50 mg/L (mean 31 mg/L).

Uses

1.Spermidine can be used in electroporation while transferring the DNA into the cell under the electrical impulse. May be used for purification of DNA-binding proteins.

2.Spermidine is also used, along with calcium chloride, for precipitating DNA onto microprojectiles for bombardment with a gene gun.

3.Spermidine has also been reported to protect the heart from aging and prolong the lifespan of mice, while in humans it was correlated with lower blood pressure. It also was found to reduce the amount of aging in yeast, flies, worms, and human immune cells by inducing autophagy.

4.Spermidine is commonly used for in vitro molecular biology reactions, particularly, in vitro transcription by phage RNA polymerases, in vitro transcription by human RNA polymerase II, and in vitro translation.

5.Spermidine increases specificity and reproducibility of Taq-mediated PCR by neutralizing and stabilizing the negative charge on DNA phosphate backbone.

6.Spermidine is, at physiological pH, a polycationic reagent that aids in enzyme digestion by forcing apart DNA molecules.
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Product description
Parameters
Product Code:
050079
CAS Number/Latin Name:
334-50-9
Active ingredients:
98.0%
Packing:
25kgs/Drum

 

Technical Data Sheet

 

Product code

050079

Product

Spermidine

Specification

98.0%,GC

CAS Number

334-50-9

Chemical Formula

C7H19N3·3HCl

 

Items

Specifications

Appearance

White to off-white powder

Identification

1HNMR confirms to structure

Solubility

Soluble in water

Loss on drying

≤1.0%

Residue on ignition

≤0.2%

Heavy metals

≤10ppm

Pb

≤0.5ppm

As

≤0.15ppm

Cd

≤2.5ppm

Hg

≤1.5ppm

Purity (GC)

≥98.0%

Total Plate Count

≤1000cfu/g

Yeast & Mold

≤100cfu/g

E.Coli

Negative

Salmonella

Negative

Staph Aureus

Negative

 

Net weight: 25kgs/Drum or Carton

Gross weight: 27.5Kgs±0.5kg/Drum

Packing size: Drum.I.D.35×H51cm; Carton 36cm×36cm×45cm

24 months under in a well-closed container and away from moisture, light, oxygen.

Packed in paper-drums or carton with two plastic-bags inside.

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